Learn how the DISPENDIX I.DOT Liquid Handler and G.PURE NGS Clean-Up Device improve genomic workflows by boosting efficiency, accuracy, and sample quality.
Rapid advancements in genomics have had a transformative impact across various fields, from deepening our understanding of disease and developing innovative treatments to enhancing agriculture and personalized medicine.
Next-generation sequencing (NGS) has provided comprehensive insights into genome structure and genetic variations, facilitating studies on rare genetic diseases and cancer genomics1. Meanwhile, single-cell genomics has offered critical insights into tissue heterogeneity and cellular mechanisms2. Integrating advanced AI and analytical tools with genomics has enhanced risk prediction and the precision of genomic studies3.
Automation and automated liquid handling have significantly advanced genomics by improving efficiency, accuracy, and throughput in various workflows, while magnetic bead cleanup solutions support researchers in achieving high-quality samples4,5.
In this article, we will explore the critical role of liquid handlers in genomics, introduce DISPENDIX’s I.DOT Liquid Handler and G.PURE NGS Clean-Up Device, and demonstrate how they can help you transform your genomics workflows!
Genomics workflows involve numerous steps requiring the transfer of tiny liquid volumes, a challenge that becomes more pronounced as the number of samples increases. It’s no secret that manual pipetting is prone to human error, which can compromise the quality and integrity of resulting samples and data6. This issue is especially problematic in highly sensitive genomics workflows, where small variations in reagent concentrations or pipetting accuracy can lead to experiment failure and unusable data — a scientist’s nightmare.
Liquid handlers play a crucial role in improving the efficiency, reliability, and flexibility of genomics workflows, enhancing the overall quality and throughput of genomic research7,8. Automated liquid handlers save valuable time, minimize waste, and cut costs by reducing the need for unnecessary experimental repeats. They also eliminate contamination risks and improve sample quality through advanced magnetic bead cleanup solutions. Moreover, they increase reproducibility, addressing the reproducibility crisis faced by researchers today9.
The I.DOT Liquid Handler is an advanced liquid dispensing tool designed for high-throughput, precise liquid handling across various scientific applications, including genomics (Fig. 1). Utilizing droplet-based, non-contact dispensing technology, it ensures exceptional accuracy, speed, and reduced reagent consumption. Key features of the I.DOT Non-Contact Dispenser include:
Figure 1. The I.DOT Non-Contact Dispenser is equipped with innovative technology, making it sure to improve the accuracy, efficiency, and reliability of your genomics workflows.
The G.PURE NGS Clean-Up Device is an advanced magnetic bead cleanup instrument designed to purify NGS libraries by removing contaminants and ensuring high-quality samples for downstream applications (Fig. 2). Key features and benefits include:
Figure 2. The G.PURE NGS Clean-Up Device supports the purification of NGS libraries for high-quality samples and results you can trust.
The DISPENDIX I.DOT Liquid Handler and the G.PURE NGS Clean-Up Device work together to streamline genomic workflows such as NGS library preparation and qPCR plate preparation by combining precise liquid handling with efficient sample purification via magnetic bead cleanup (Table 1). The I.DOT Liquid Handler ensures accurate and reproducible dispensing of reagents and samples, accommodating various volumes and liquid types, which is crucial for setting up genomic assays and high-throughput sequencing projects. Meanwhile, the G.PURE NGS Clean-Up Device efficiently removes contaminants from NGS libraries, delivering high-purity nucleic acids for sequencing.
Table 1. Comparison of the I.DOT/G.PURE bundle against other liquid handling methods.
Together, these devices enhance workflow efficiency by reducing hands-on time and speeding up sample preparation and purification processes. The I.DOT Non-Contact Dispenser’s automated dispensing and the G.PURE NGS Clean-Up Device’s high-throughput purification capabilities significantly cut down manual handling and the potential for human error, leading to faster turnaround times. Additionally, the combination ensures tip-top sample quality with precise reagent volumes and magnetic bead cleanup, resulting in contaminant-free nucleic acids and more consistent and reliable sequencing outcomes.
Conclusion
The rapid advancements in genomics have revolutionized various fields, with innovations like NGS and single-cell genomics providing deep insights into cellular heterogeneity and disease mechanisms. Automated liquid handling systems, such as the I.DOT Liquid Handler and the magnetic bead cleanup-based G.PURE NGS Clean-Up Device play a crucial role by combining precise, high-throughput dispensing with efficient sample purification. These technologies enhance workflow efficiency, accuracy, and sample quality, reducing hands-on time and minimizing human error.
Join countless researchers who trust the G.PURE NGS Clean-Up Device for their sample purification needs. Enhance your results, save time, and focus on what truly matters — your groundbreaking research. Our state-of-the-art magnetic bead cleanup solution ensures that you achieve pristine, high-purity samples every time, making your research faster, easier, and more reliable. Book a demo today!
Discover how NGS library prep automation transforms genomics with advanced liquid handling and DNA clean-up technologies.
Discover the impact of advanced automated liquid handlers in genomics research.
The role of automated DNA clean-up systems, featuring AMPure XP beads, in enhancing the accuracy, efficiency, and reproducibility of genomics is...
