Dose Response Curves
For Efficient Drug Discovery

Dose Response Curves for Drug Discovery

Dose response curves are graphical representations of the relationship between the concentration or dose of a drug or compound and its biological response. In drug discovery, these curves are used to assess the potency and efficacy of a drug candidate. The curve typically plots the drug concentration or dose on the x-axis (usually on a logarithmic scale) and the corresponding biological response, such as inhibition or stimulation, on the y-axis.

Dose response curves provide valuable information about the drug's pharmacological activity, including the effective concentration or dose required to achieve a desired response, as well as the maximum response attainable. These curves are essential for evaluating drug potency, determining appropriate dosages, and understanding the therapeutic window of a drug candidate.

I.DOT Liquid Hander

The I.DOT Liquid Handler can be instrumental in supporting the generation of dose-response curves in drug discovery. By precisely and accurately dispensing small volumes of drug concentrations onto assay plates, it enables researchers to create a wide range of concentrations for dose-response studies.

The non-contact dispensing technology minimizes cross-contamination and ensures consistent droplet size, resulting in reliable and reproducible data. With the I.DOT Non-Contact Dispenser, scientists can efficiently prepare assay plates with varying drug concentrations, allowing them to perform dose-response experiments and obtain the necessary data points to construct dose-response curves. This automated dispenser enhances the efficiency, accuracy, and reproducibility of dose-response studies in drug discovery.

The Power of Resolution

The I.DOT Liquid Handler offers a significant advantage over its competitors in drug discovery research. While competitors can only dispense increments of 2.5 nanoliters (nL), the I.DOT stands out by providing droplet dispensing with a resolution as low as 0.1 nL. This capability enables researchers to create linear dose-response curves without compromising precision. By precisely controlling the dispensing volume, the I.DOT allows for a finer manipulation of drug concentrations, resulting in more accurate and reliable data.

This advantage empowers scientists to optimize their experiments, generate comprehensive dose-response curves, and gain deeper insights into the pharmacological activity of their drug candidates.