Dose Response Curves
For Efficient Drug Discovery

Dose Response Curves for Drug Discovery

Dose-response curves are graphical representations of the relationship between the concentration or dose of a drug or compound and its biological response. In drug discovery, these curves are used to assess the potency and efficacy of a drug candidate. The curve typically plots the drug concentration or dose on the x-axis (usually on a logarithmic scale) and the corresponding biological response, such as inhibition or stimulation, on the y-axis. Dose-response curves provide valuable information about the drug's pharmacological activity, including the effective concentration or dose required to achieve a desired response, as well as the maximum response attainable. These curves are essential for evaluating drug potency, determining appropriate dosages, and understanding the therapeutic window of a drug candidate.

I.DOT Liquid Hander

The I.DOT liquid handler can be instrumental in supporting the generation of dose-response curves in drug discovery. By precisely and accurately dispensing small volumes of drug concentrations onto assay plates, it enables researchers to create a wide range of concentrations for dose-response studies.

The non-contact dispensing technology minimizes cross-contamination and ensures consistent droplet size, resulting in reliable and reproducible data. With the I.DOT dispenser, scientists can efficiently prepare assay plates with varying drug concentrations, allowing them to perform dose-response experiments and obtain the necessary data points to construct dose-response curves. This automated dispenser enhances the efficiency, accuracy, and reproducibility of dose-response studies in drug discovery.

The Power of Resolution

The I.DOT liquid handler offers a significant advantage over its competitors in drug discovery research. While competitors can only dispense increments of 2.5 nanoliters (nL), the I.DOT stands out by providing droplet dispensing with a resolution as low as 0.1 nanoliters (nL). This capability enables researchers to create linear dose-response curves without compromising precision. By precisely controlling the dispensing volume, the I.DOT allows for a finer manipulation of drug concentrations, resulting in more accurate and reliable data.

This advantage empowers scientists to optimize their experiments, generate comprehensive dose-response curves, and gain deeper insights into the pharmacological activity of their drug candidates.