Publication Highlight: I.DOT facilitates nl to µl volume dispensing for highly miniaturized cell assays using droplet microarray–mass spectrometry imaging platform

I.DOT facilitates nl to µl volume dispensing for highly miniaturized cell assays using droplet microarray–mass spectrometry imaging platform

Employing DMA-MSI platform, they have demonstrated a highly miniaturized cell-based screening assay (downscaling 5 µl to 40 nL and only 10 cells per spot using I.DOT) with a label-free quantitative protein readout using MALDI–MSI.

This platform offers several advantages compared to other available technologies:

  • Label free proteomic readouts
  • Direct cell culture on DMA-ITO
  • Miniaturization of cell-based assays compared with standard MALDI target plates
  • Analysis of minimal numbers of cells per spot, down to single the cell level
  • A faster overall sample preparation workflow

Access the free research article for more information.

Download: https://doi.org/10.1002/adbi.202000279

More from Our Blog