What is High-Throughput Screening?

Automation has unlocked efficiencies and expanded scale across multiple industries, and with high-throughput screening (HTS), drug discovery is no exception. Automation has been accelerating progress in drug discovery developments and has opened up opportunities to scale up high throughput tests. Implementing automated equipment results, experiments become more accurate, repeatable, scalable, and productivity increases. Hence, costs of materials and labor costs decrease.

What is High-Throughput Screening?

HTS uses automated equipment in a drug discovery process to rapidly test a large number of chemical and/or biological compounds. These methods are extensively used in the pharmaceutical industry. By leveraging automation to quickly test the activity of many molecules, usually drugs. They accelerate target analysis, as large-scale compound libraries can quickly be screened in a cost-effective way. For instance, in pharmacological targets, HTS is a useful tool.

 

High-Throughput Screening in Drug Discovery

The process consists of identifying and assaying a wide range of biological modulators and effectors against a particular target. In addition to industrial scientists, academic researchers also use it. Various types of libraries can be screened with HTS assays, including combinatorial chemistry, genomics, protein, and peptide libraries. While screening large compound libraries at rates exceeding a few thousand compounds per day or week. The HTS technique accelerates drug discovery with several steps, including the identification of targets, preparation of reagents,  management of compounds, design of assays, and the screening of libraries.

 

Miniaturization for HTS

Miniaturization is a challenge currently facing high-throughput screening for drug discovery. As a result to cost savings, it’s ideal to use as few samples as possible while at the same time produce reliable results.

Through DISPENDIX’s liquid handlers, miniaturization of the screening process can be achieved. Therefore, reducing the costs of the process even further than current high-throughput screening methods.

NEWEST TECHNOLOGY IN LIQUID HANDLING FOR FAST AND ACCURATE RESULTS EVERYTIME!

The I.DOT HT allows users to quickly and efficiently screen large compound libraries at a quick rate while saving substantial amount of costs and increasing the throughput. I.DOT HT optimizes your workflow to bring intuitive automation, precision and speed to every lab.

DISPENDIX is changing the way researchers think about the automation of their genomics and drug discovery workflows.

With precise transfers down to 8 nL, the I.DOT HT enables reaction miniaturization, allowing researchers to run up to 10x as many samples for the same cost to their lab.

IMPROVED EFFICIENCY ACROSS APPLICATIONS

Drug Discovery

Equipped with 384 source well plate that provides flexibility to test up to 384 different compounds.

High-Throughput Screening

Create multiple permutations of drug concentrations across the well plate with different drug mixtures in each well.

Assay Development

Dispenses small molecules, nucleic acids, drugs, etc. in a multiplexed manner and in direct dilution steps. Ideal for designing individual experiments.

Genomics and Proteomics

Leverages miniaturization, low-volume dispensing and low dead volume to efficiently dispense for NGS prep, PCR, extraction and clean-ups.

There are many features and benefits that come with the I.DOT HT, such as eliminating carry-over and cross contamination, To learn more on how to streamline your workflow and book a demo today

Julie DiRosa, Product Marketing Manager

More from Our Blog